This morning I had an issue where after updating the desktop Zune software to the new version (4.8) Visual Studio (running the NoDo development tools*) became unable to deploy or debug apps running on a phone. This was the case with a phone running a Nodo version (specifically 7.0.7392) and another phone running a pre-NoDo build.
Obviously, losing the ability to deploy to and test on an actual device was of concern.
After a few worried minutes involving restarting the software (Zune & Visual Studio) and rebooting the phone we resolved this issue by rebooting the PC.
Hopefully knowing that a reboot may be required may save someone else a bit of time.
* I have a separate machine running the Mango SDK RC which wasn't affected.